Lee M A, Meltzer H Y
Department of Psychiatry, Case Western Reserve University, Cleveland, OH 44106.
Drug Alcohol Depend. 1994 Jun;35(3):217-22. doi: 10.1016/0376-8716(94)90077-9.
Previous studies have suggested that chronic cocaine administration may affect serotonergic function and that serotonin (5-HT) may be of importance in cocaine craving. Ten male cocaine addicts and 28 male normal controls were challenged with MK-212 (6-chlor-2-[1-piperazinyl]-pyrazine) (20 mg), a direct acting 5-HT receptor agonist which has affinity for a variety of 5-HT receptor subtypes, and placebo, on separate days. The plasma cortisol and prolactin (PRL) concentrations and oral body temperature responses to MK-212 and placebo were compared between groups. The temperature response to MK-212 was significantly blunted in cocaine addicts compared to normal controls. However, the plasma cortisol and PRL responses to MK-212 did not differ between the two groups. These results suggest selective alteration of presynaptic 5-HT1A or postsynaptic 5-HT2A/2C function in cocaine addicts.
先前的研究表明，长期使用可卡因可能会影响血清素能功能，并且血清素（5-羟色胺，5-HT）可能在可卡因成瘾方面具有重要作用。10名男性可卡因成瘾者和28名男性正常对照者在不同日期分别接受了MK-212（6-氯-2-[1-哌嗪基]-吡嗪）（20毫克）和安慰剂的激发试验，MK-212是一种对多种5-HT受体亚型具有亲和力的直接作用5-HT受体激动剂。比较了两组对MK-212和安慰剂的血浆皮质醇和催乳素（PRL）浓度以及口腔体温反应。与正常对照者相比，可卡因成瘾者对MK-212的体温反应明显减弱。然而，两组对MK-212的血浆皮质醇和PRL反应并无差异。这些结果表明可卡因成瘾者的突触前5-HT1A或突触后5-HT2A/2C功能发生了选择性改变。
