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Over-additive anticonvulsant effect of memantine and NBQX in kindled rats.

作者信息

Löscher W, Hönack D

机构信息

Department of Pharmacology, Toxicology, and Pharmacy, School of Veterinary Medicine, Hannover, Germany.

出版信息

Eur J Pharmacol. 1994 Jul 1;259(2):R3-5. doi: 10.1016/0014-2999(94)90514-2.

DOI:10.1016/0014-2999(94)90514-2
PMID:7957602
Abstract

We investigated the anticonvulsant and adverse effects of various dose combinations of the AMPA receptor antagonist NBQX (2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(F)quinoxaline) and the low-affinity, rapidly channel blocking NMDA receptor antagonist memantine in the kindling model of epilepsy. While memantine was ineffective when given alone, co-administration with NBQX markedly potentiated the increase in focal seizure threshold induced by NBQX alone. This synergistic (i.e. over-additive) interaction was seen at doses of both drugs which did not induce behavioural adverse effects. The data substantiate that combinations of AMPA and NMDA receptor antagonists provide a new strategy for the treatment of epileptic seizures.

摘要

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