一氧化氮作为胆囊收缩素-8和五肽胃泌素胃保护作用的介质。

Nitric oxide as mediator of the gastroprotection by cholecystokinin-8 and pentagastrin.

作者信息

Stroff T, Lambrecht N, Peskar B M

机构信息

Department of Experimental Clinical Medicine, Ruhr-University of Bochum, Germany.

出版信息

Eur J Pharmacol. 1994 Jul 21;260(1):R1-2. doi: 10.1016/0014-2999(94)90019-1.

DOI:10.1016/0014-2999(94)90019-1

PMID:7957617

Abstract

Cholecystokinin-8 and pentagastrin protect against ethanol-induced gastric mucosal lesions in rats. The protective effect is antagonized by the nitric oxide (NO) synthase inhibitor, NG-nitro-L-arginine. The inhibitory action of NG-nitro-L-arginine is reversed by L-arginine, but not D-arginine. The findings suggest that NO is involved in the gastroprotection induced by both peptides.

摘要

胆囊收缩素-8和五肽胃泌素可预防大鼠乙醇诱导的胃黏膜损伤。一氧化氮（NO）合酶抑制剂NG-硝基-L-精氨酸可拮抗这种保护作用。L-精氨酸可逆转NG-硝基-L-精氨酸的抑制作用，而D-精氨酸则不能。这些发现表明，NO参与了这两种肽诱导的胃保护作用。