一氧化氮在降钙素基因相关肽的抗溃疡活性中的作用。
A role for nitric oxide in the anti-ulcer activity of calcitonin gene-related peptide.
作者信息
Clementi G, Caruso A, Prato A, De Bernardis E, Fiore C E, Amico-Roxas M
机构信息
Institute of Pharmacology, University of Catania School of Medicine, Italy.
出版信息
Eur J Pharmacol. 1994 Apr 21;256(2):R7-8. doi: 10.1016/0014-2999(94)90252-6.
PMID:8050460
Abstract
The anti-ulcer activity of calcitonin gene-related peptide (CGRP) was inhibited, in a dose-dependent manner, by pretreatment with NG-nitro-L-arginine methyl ester, an inhibitor of nitric oxide synthase. Our results suggest that endogenous nitric oxide is involved in the anti-ulcer activity of CGRP.
摘要
降钙素基因相关肽（CGRP）的抗溃疡活性，以剂量依赖的方式，被一氧化氮合酶抑制剂NG-硝基-L-精氨酸甲酯预处理所抑制。我们的结果表明，内源性一氧化氮参与了CGRP的抗溃疡活性。
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