Torte M P, Courjon J H, Flandrin J M, Magnin M, Magenes G
Laboratoire Vision et Motricite, INSERM U94, Bron, France.
Exp Brain Res. 1994;99(3):441-54. doi: 10.1007/BF00228981.
Bilateral surgical lesions of the flocculus or the nodulo-uvular lobes were performed in the cat. Effects of these lesions on optokinetic and optokinetic afternystagmus OKAN), vestibulo-ocular reflex (VOR), visual suppression, and adaptation and habituation of VOR were studied using an identical experimental protocol. After flocculectomy, all these functions were impaired, except for habituation. Long-term postoperative recordings only revealed a recovery of the suppression of VOR, suggesting a limited contribution of the flocculus to this function. After nodulo-uvulectomy, only habituation and OKAN were modified. When the lesion was restricted to part of the uvula, OKAN duration was decreased. For other lesions involving the uvula together with the nodulus and/or the lobules VII-VIII,OKAN duration was increased. Habituation was lost after destruction of the nodulo-uvular lobes. When this latter structure was damaged, the retention component of habituation was selectively impaired, sparing the acquisition. Additional lesions outside the vestibulocerebellum appeared necessary to suppress the two components. Comparison of results obtained after flocculectomy and after nodulouvulectomy confirms and extends to non-primate species the concept of a "differential control" of adaptation and habituation by distinct vestibulocerebellar structures.
对猫进行了绒球或小结-悬雍垂叶的双侧手术损伤。使用相同的实验方案研究了这些损伤对视动性眼震和视动性眼震后眼震（OKAN）、前庭眼反射（VOR）、视觉抑制以及VOR的适应和习惯化的影响。绒球切除术后，除习惯化外，所有这些功能均受损。术后长期记录仅显示VOR抑制的恢复，提示绒球对该功能的贡献有限。小结-悬雍垂叶切除术后，仅习惯化和OKAN发生改变。当损伤局限于悬雍垂的一部分时，OKAN持续时间缩短。对于涉及悬雍垂以及小结和/或小叶VII-VIII的其他损伤，OKAN持续时间延长。小结-悬雍垂叶破坏后习惯化丧失。当该结构受损时，习惯化的保持成分选择性受损，而获得成分未受影响。在前庭小脑之外进行额外损伤似乎是抑制这两个成分所必需的。比较绒球切除术后和小结-悬雍垂叶切除术后获得的结果，证实并将不同前庭小脑结构对适应和习惯化的“差异控制”概念扩展到非灵长类动物。
