Navarro X, Verdú E, Butí M
Department of Cell Biology and Physiology, Faculty of Medicine, Universitat Autònoma de Barcelona, Bellaterra, Spain.
Exp Neurol. 1994 Oct;129(2):217-24. doi: 10.1006/exnr.1994.1163.
Functional reinnervation of sweat glands (SGs), skin, and muscle in the mouse paw after sciatic nerve lesions was evaluated to allow comparisons of the regeneration efficiency of different functional types of nerve fibers. In four groups of mice the sciatic nerve was crushed, sectioned, and left unrepaired or repaired by suture or tubulization. Reappearance of SG secretion and pinprick responses occurred slightly earlier than recordings of compound muscle and nerve action potentials in all groups. The degree of reinnervation, with respect to preoperative control values, of SGs and skin nociceptors was higher than the amplitude of the action potentials, mainly when the nerve injury was severe. The chances for recovery progressively decreased with the severity of the lesion, affecting the larger nerve fibers most. These results indicate that, after injuries of peripheral nerves, all types of nerve fibers are able to regenerate in the mouse, although small size fibers (sudomotor and nociceptive) allow for a higher degree of functional recovery than large myelinated fibers (skeletomotor and sensory).
评估了坐骨神经损伤后小鼠爪部汗腺（SGs）、皮肤和肌肉的功能性再支配情况，以便比较不同功能类型神经纤维的再生效率。在四组小鼠中，对坐骨神经进行挤压、切断，任其不修复或通过缝合或套管法进行修复。在所有组中，SG分泌和针刺反应的重新出现略早于复合肌肉和神经动作电位的记录。相对于术前对照值，SGs和皮肤伤害感受器的再支配程度高于动作电位的幅度，主要是在神经损伤严重时。恢复的机会随着损伤的严重程度而逐渐降低，对较大的神经纤维影响最大。这些结果表明，在周围神经损伤后，所有类型的神经纤维在小鼠中都能够再生，尽管小尺寸纤维（汗腺运动和伤害感受性）比大的有髓纤维（骨骼运动和感觉性）具有更高程度的功能恢复。
