D'Amelio R, Stroffolini T, Nisini R, Matricardi P M, Rapicetta M, Spada E, Napoli A, Pasquini P
Laboratorio di Immunologia, Aeronautica Militare, Rome, Italy.
Eur J Epidemiol. 1994 Feb;10(1):105-7. doi: 10.1007/BF01717462.
In 1990, a prospective serological survey to estimate the rate of clinical and inapparent infection with hepatitis B virus was performed in a cohort of 1324 soldiers, 18-24 years old, during an eight-month period in Italy. At the time of enrollment the prevalence of hepatitis B markers was 4.6% (0.7% subjects positive for hepatitis B surface antigen [HBsAg], 3.0% positive for antibody to hepatitis B surface antigen [anti-HBs], and 0.9% positive for antibody to hepatitis B core antigen [anti-HBc] alone. Among the 1263 susceptible subjects who were followed-up, only 2 (0.24/100 person-years of exposure) had seroconversion for HBV markers, none of which was associated with clinical illness. Among the 9 subjects HBsAg-positive at the time of enrollment, 1 (11.2%) had lost HBsAg at the end of follow-up. These data show a low spread of HBV infection among Italian young generations.
1990年，在意大利对1324名年龄在18至24岁的士兵进行了为期八个月的前瞻性血清学调查，以估计乙型肝炎病毒的临床感染率和隐性感染率。入组时，乙型肝炎标志物的患病率为4.6%（0.7%的受试者乙型肝炎表面抗原[HBsAg]呈阳性，3.0%的受试者乙型肝炎表面抗原抗体[抗-HBs]呈阳性，0.9%的受试者仅乙型肝炎核心抗原抗体[抗-HBc]呈阳性）。在接受随访的1263名易感受试者中，只有2人（0.24/100人年暴露）出现了HBV标志物血清转换，且均与临床疾病无关。在入组时HBsAg呈阳性的9名受试者中，1人（11.2%）在随访结束时失去了HBsAg。这些数据表明，HBV感染在意大利年轻一代中的传播率较低。
