Scott R M, Schneider R J, Snitbhan R, Karwacki J J
Am J Epidemiol. 1981 May;113(5):520-8. doi: 10.1093/oxfordjournals.aje.a113127.
To determine the incidence of clinical and inapparent hepatitis in a US military population stationed in Thailand, the authors prospectively studied a cohort of 326 men during one year. Clinical hepatitis A occurred in one man (clinical attack rate = 3.1/1000 men/year), and clinical hepatitis B was found in four men (clinical attack rate = 12.3/1000 men/year). No non-A, non-B hepatitis was identified. There was no serologically identified inapparent hepatitis A but inapparent hepatitis B occurred in 17 men. The apparent/inapparent ratio for hepatitis B was 1:4.25. Serotype analysis suggested that hepatitis B virus largely originated from Thai contacts, although 23% of cases were derived from western sources. To determine the relative contribution of 16 statistically significant (out of 67 studied) behavioral variables to the transmission of HBV, a factor analysis and a multivariate correlation analysis were employed. Factor analysis indicated that social and sexual contact with the indigenous population, including prostitutes, residence within the Thai community and marijuana use were behavioral areas that were associated with the acquisition of hepatitis B. Residence in the Thai community during the first four-month period in Thailand, sexual contact with a prostitute during the third four-month period, and ever having maintained a Thai mistress were found to be significant and independent risk factors by multiple regression analysis.
为确定驻扎在泰国的美国军人中临床型和隐匿型肝炎的发病率，作者对一组326名男性进行了为期一年的前瞻性研究。一名男性发生临床型甲型肝炎（临床发病率=3.1/1000人/年），四名男性被发现患有临床型乙型肝炎（临床发病率=12.3/1000人/年）。未发现非甲非乙型肝炎。未发现血清学确诊的隐匿型甲型肝炎，但17名男性发生了隐匿型乙型肝炎。乙型肝炎的显性/隐性比例为1:4.25。血清型分析表明，乙型肝炎病毒主要源自与泰国人的接触，尽管23%的病例来自西方。为确定16个具有统计学意义的行为变量（在研究的67个变量中）对乙肝病毒传播的相对影响，采用了因子分析和多变量相关分析。因子分析表明，与当地人群（包括妓女）的社交和性接触、在泰国社区居住以及吸食大麻是与感染乙型肝炎相关的行为领域。多元回归分析发现，在泰国的前四个月期间居住在泰国社区、在第三个四个月期间与妓女发生性接触以及曾有泰国情妇是重要且独立的危险因素。
