Ovarian derived prorenin-angiotensin cascade in human reproduction.

OBJECTIVE

To review the available literature concerning the renin-angiotensin system of the human and animal ovary and to outline the clinical relevance of this system.

DESIGN

The location, function, and regulation of the components of the ovarian prorenin cascade are described. The possible functions of this system as well as its association with common gynecologic problems are also given.

CONCLUSIONS

The ovary contains a complete cascade whose end product is the formation of angiotensin II. Angiotensin II may have a role in steroid synthesis, oocyte maturation, ovulation, and corpus luteum formation. Further, aberrations in this system are associated with ovarian tumors, ectopic pregnancy, pre-eclampsia, and ovarian hyperstimulation syndrome.