Schultz G, Khaw P T, Oxford K, MaCauley S, Van Setten G, Chegini N
Department of Obstetrics/Gynaecology, University of Florida, Gainesville 32610-0294.
Eye (Lond). 1994;8 ( Pt 2):184-7. doi: 10.1038/eye.1994.43.
Protein growth factors regulate many of the processes in vitro that are essential for the process of normal ocular wound healing, including migration, mitosis and differentiation of cells. This has led to the hypothesis that peptide growth factors play key roles in regulating normal ocular wound healing in vivo. A corollary to this concept is that insufficient action of growth factors causes impaired healing, and prolonged action of growth factors produces excessive scarring. If both of these concepts are correct, then the addition of exogenous protein growth factors should enhance healing of chronic ocular wounds and reducing prolonged actions of growth factors should limit excessive scarring. Although much remains to be understood about the role of growth factors in ocular development and wound healing, results of a substantial number of laboratory and clinical experiments indicate that these hypotheses are generally correct. This article reviews the results of pre-clinical experiments and clinical trials investigating the roles of protein growth factors in ocular development and wound healing.
蛋白质生长因子调节体外许多对正常眼表伤口愈合过程至关重要的过程，包括细胞的迁移、有丝分裂和分化。这导致了这样一种假说，即肽生长因子在体内调节正常眼表伤口愈合中起关键作用。这一概念的一个推论是，生长因子作用不足会导致愈合受损，而生长因子的长期作用会产生过度瘢痕形成。如果这两个概念都是正确的，那么添加外源性蛋白质生长因子应该能促进慢性眼表伤口的愈合，而减少生长因子的长期作用应该能限制过度瘢痕形成。尽管关于生长因子在眼发育和伤口愈合中的作用仍有许多有待了解，但大量实验室和临床实验的结果表明这些假说是普遍正确的。本文综述了临床前实验和临床试验的结果，这些实验研究了蛋白质生长因子在眼发育和伤口愈合中的作用。
