Gajkowska B, Domańska-Janik K, Viron A
Department of Neurochemistry, Polish Academy of Sciences, Warsaw.
Folia Histochem Cytobiol. 1994;32(2):71-7.
This study describes immunocytochemical distribution of the protein kinase C (PKC) subspecies: alpha, beta and gamma in the CAI sector of gerbil hippocampus. Immunolabelling was performed with 10 nm gold-antibody complexes against each of the PKC subspecies. The subspecies of PKC were expressed specifically in different populations of hippocampal cells. An enhanced PKC immunoreactivity was noted in the animals after ischemia. We propose that this phenomenon reflects an activation of PKC in the early phase of brain ischemia.
本研究描述了蛋白激酶C（PKC）亚型α、β和γ在沙鼠海马CAI区的免疫细胞化学分布。采用针对各PKC亚型的10纳米金标抗体复合物进行免疫标记。PKC亚型在海马细胞的不同群体中特异性表达。在缺血后的动物中观察到PKC免疫反应性增强。我们认为这种现象反映了脑缺血早期PKC的激活。
