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Effect of transient forebrain ischemia on superoxide dismutases in gerbil hippocampus.

作者信息

Ohtsuki T, Matsumoto M, Suzuki K, Taniguchi N, Kamada T

机构信息

First Department of Internal Medicine, Osaka University Medical School, Japan.

出版信息

Brain Res. 1993 Aug 27;620(2):305-9. doi: 10.1016/0006-8993(93)90171-i.

DOI:10.1016/0006-8993(93)90171-i
PMID:8369963
Abstract

Substantial generation of oxygen-derived free radicals has been implicated in pathophysiology of ischemic brain damage. Immunoreactive mitochondrial manganese and cytosolic copper-zinc superoxide dismutases, initial and essential enzymes to scavenge superoxide radical anions, increased in the gerbil hippocampal neurons after transient forebrain ischemia. Neuronal cells responded to oxidative stress in ischemia and induced the protective mechanism to increase superoxide dismutases.

摘要

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