Arora M, Jaroudi K A, Hamilton C J, Dayel F
Department of Obstetrics and Gynecology, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
Eur J Obstet Gynecol Reprod Biol. 1994 Jun 30;55(3):179-82. doi: 10.1016/0028-2243(94)90035-3.
To evaluate the effects of Interceed TC7 (Johnson & Johnson Medical, New Brunswick, NJ) and gamma-irradiated human amniotic membrane graft in prevention of postoperative adhesions in the rabbit uterine horn model.
A conventional animal laboratory.
Virgin, female New Zealand white rabbits.
Both uterine horns were subjected to clean transverse cuts 1 cm apart at the antimesenteric border. The left uterine horn was left uncovered in each case to act as a control. The right uterine horn was randomly covered with either Interceed TC7 or human amniotic membrane.
Adhesion score was evaluated 4 weeks after the initial surgery. Samples of each uterine horn were collected for histopathological studies, and subserosal inflammatory score.
Interceed resulted in higher adhesion scores and subserosal inflammation score than the control side (P = 0.03 and 0.05, respectively). A similar difference was found for amniotic membrane when compared with the uncovered control side (P = < 0.01 and 0.01, respectively).
Interceed TC7 failed to have the preventive effect on adhesion formation it is claimed to possess. Amniotic membrane performed poorly too. Therefore, gentle tissue handling, irrigation and good surgical skills remain the most important prerequisite for adhesion prevention.
评估Interceed TC7（强生医疗公司，新泽西州新不伦瑞克）和γ射线辐照的人羊膜移植片在兔子宫角模型中预防术后粘连的效果。
常规动物实验室。
未生育的雌性新西兰白兔。
在每个兔的子宫角的系膜对侧缘进行相距1 cm的清洁横切。每种情况下，左侧子宫角不覆盖任何材料作为对照。右侧子宫角随机覆盖Interceed TC7或人羊膜。
在初次手术后4周评估粘连评分。采集每个子宫角的样本进行组织病理学研究及浆膜下炎症评分。
与对照侧相比，Interceed导致更高的粘连评分和浆膜下炎症评分（分别为P = 0.03和0.05）。与未覆盖的对照侧相比，羊膜也有类似差异（分别为P = < 0.01和0.01）。
Interceed TC7未能发挥其宣称的预防粘连形成的作用。羊膜的效果也不佳。因此，轻柔的组织操作、冲洗和良好的手术技巧仍然是预防粘连最重要的前提条件。
