反式环氧琥珀酰-L-亮氨酰胺（4-胍基）-丁烷（E-64）可能通过结合于S1亚位点来抑制胰蛋白酶催化的水解反应。 - Suppr | 超能文献

trans-epoxysuccinyl-L-leucylamido (4-guanidino)-butane (E-64) inhibits trypsin-catalysed hydrolysis possibly by binding in the S1-subsite.

作者信息

Sreedharan S K, Shah H N, Brocklehurst K

机构信息

Department of Biochemistry, Queen Mary & Westfield College, University of London, U.K.

出版信息

Biochem Soc Trans. 1994 May;22(2):212S. doi: 10.1042/bst022212s.

DOI:10.1042/bst022212s

Abstract

摘要

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trans-epoxysuccinyl-L-leucylamido (4-guanidino)-butane (E-64) inhibits trypsin-catalysed hydrolysis possibly by binding in the S1-subsite.反式环氧琥珀酰-L-亮氨酰胺（4-胍基）-丁烷（E-64）可能通过结合于S1亚位点来抑制胰蛋白酶催化的水解反应。

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2

Demonstration that 1-trans-epoxysuccinyl-L-leucylamido-(4-guanidino) butane (E-64) is one of the most effective low Mr inhibitors of trypsin-catalysed hydrolysis. Characterization by kinetic analysis and by energy minimization and molecular dynamics simulation of the E-64-beta-trypsin complex.证明反式-环氧琥珀酰-L-亮氨酰胺基-(4-胍基)丁烷（E-64）是胰蛋白酶催化水解作用最有效的低分子量抑制剂之一。通过动力学分析以及对E-64-β-胰蛋白酶复合物进行能量最小化和分子动力学模拟进行表征。

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Demonstration that 1-trans-epoxysuccinyl-L-leucylamido-(4-guanidino) butane (E-64) is one of the most effective low Mr inhibitors of trypsin-catalysed hydrolysis. Characterization by kinetic analysis and by energy minimization and molecular dynamics simulation of the E-64-beta-trypsin complex.证明反式-环氧琥珀酰-L-亮氨酰胺基-(4-胍基)丁烷（E-64）是胰蛋白酶催化水解作用最有效的低分子量抑制剂之一。通过动力学分析以及对E-64-β-胰蛋白酶复合物进行能量最小化和分子动力学模拟进行表征。

Biochem J. 1996 Jun 15;316 ( Pt 3)(Pt 3):777-86. doi: 10.1042/bj3160777.