Persson P G, Karlén P, Bernell O, Leijonmarck C E, Broström O, Ahlbom A, Hellers G
Division of Epidemiology, Karolinska Institutet, Stockholm, Sweden.
Gastroenterology. 1994 Dec;107(6):1675-9. doi: 10.1016/0016-5085(94)90807-9.
BACKGROUND/AIMS: To study the association between Crohn's disease and cancer, we performed a population-based study of 1251 subjects with Crohn's disease diagnosed in Stockholm from 1955 to 1984 and followed in both the National Cancer Register and the National Cause-of-Death Register until 1989.
For comparisons, regional cancer incidence rates in Stockholm County were used together with individually computed person-years at risk in the Crohn's disease cohort.
Overall, 69 malignancies occurred among 67 individuals as compared with 59.80 expected malignancies (standardized morbidity ratio [SMR] = 1.15; 95% confidence interval, 0.90-1.46). An excess number of cancers of the upper gastrointestinal tract (SMR, 3.05; 95% confidence interval, 1.67-5.11) was observed, mainly because of an increased number of cancers of the small intestine (SMR, 15.64; 95% confidence interval, 4.26-40.06). An increased occurrence of urinary bladder cancer was also observed (SMR, 2.68; 95% confidence interval, 1.08-5.53).
The occurrence of colorectal cancer was not increased.
背景/目的：为研究克罗恩病与癌症之间的关联，我们开展了一项基于人群的研究，对1955年至1984年在斯德哥尔摩被诊断为克罗恩病的1251名受试者进行了研究，并在国家癌症登记处和国家死亡原因登记处进行随访，直至1989年。
为进行比较，使用了斯德哥尔摩县的区域癌症发病率以及克罗恩病队列中单独计算的个体风险人年数。
总体而言，67名个体中发生了69例恶性肿瘤，而预期恶性肿瘤为59.80例（标准化发病比[SMR]=1.15；95%置信区间，0.90 - 1.46）。观察到上消化道癌症数量过多（SMR，3.05；95%置信区间，1.67 - 5.11），主要是因为小肠癌症数量增加（SMR，15.64；95%置信区间，4.26 - 40.06）。还观察到膀胱癌的发生率有所增加（SMR，2.68；95%置信区间，1.08 - 5.53）。
结直肠癌的发生率并未增加。
