Hunt C M, Washington K
Department of Medicine, Duke University Medical Center, Durham, North Carolina.
Gastroenterology. 1994 Dec;107(6):1844-7. doi: 10.1016/0016-5085(94)90830-3.
Acute self-limited liver disease has been associated with tetracycline use. However, severe prolonged cholestatic hepatitis and bile duct paucity have not been previously attributed to tetracyclines. Hepatitis, characterized by prolonged jaundice, severe pruritus, and moderate increased transaminase values, occurred within 2 months of ingesting tetracyclines in two female patients. Serum bilirubin levels normalized 12 and 34 months after tetracycline ingestion. Liver histology revealed bile duct paucity, severe cholestasis, and minimal necrosis and inflammation. Tetracyclines may infrequently induce bile duct paucity and prolonged, severe, and reversible cholestasis.
急性自限性肝病与四环素的使用有关。然而，严重的迁延性胆汁淤积性肝炎和胆管稀少此前尚未归因于四环素。两名女性患者在摄入四环素后2个月内出现了以迁延性黄疸、严重瘙痒和转氨酶值中度升高为特征的肝炎。四环素摄入后12个月和34个月血清胆红素水平恢复正常。肝脏组织学检查显示胆管稀少、严重胆汁淤积以及轻微坏死和炎症。四环素可能很少诱发胆管稀少以及迁延性、严重且可逆的胆汁淤积。
