前列环素对离体犬肾动脉对血栓素A2类似物U46619收缩反应的抑制作用。

Inhibitory effect of vapiprost on contractile responses of isolated dog renal arteries to thromboxane A2 analogue, U46619.

Sakanashi M, Matsuzaki T, Noguchi K, Nakasone J, Itomine T, Uza M, Toyama F, Higuchi M

Department of Pharmacology, School of Medicine, University of the Ryukyus, Japan.

Gen Pharmacol. 1994 Jul;25(4):617-22. doi: 10.1016/0306-3623(94)90236-4.

Abstract

Cumulative administrations of U46619, a thromboxane A2 analogue, and prostaglandin (PG) F2 alpha produced concentration-dependent contractions of isolated dog renal arterial preparations, which were significantly and concentration-dependently inhibited by vapiprost. 2. A bolus administration of U46619 or PGF2 alpha produced sustained contracture of these preparations, which was concentration-dependently relaxed by cumulative vapiprost. 3. Results indicate that vapiprost inhibits U46619- and PGF2 alpha-induced dog renal arterial contractions through antagonism for so-called TP receptors.

摘要

血栓素A2类似物U46619和前列腺素（PG）F2α的累积给药可使离体犬肾动脉制剂产生浓度依赖性收缩，而瓦吡前列素可显著且浓度依赖性地抑制这种收缩。2. 一次性给予U46619或PGF2α可使这些制剂产生持续性挛缩，而累积给予瓦吡前列素可使其浓度依赖性松弛。3. 结果表明，瓦吡前列素通过拮抗所谓的TP受体来抑制U46619和PGF2α诱导的犬肾动脉收缩。