氯胺酮抑制雷尼替丁和毒扁豆碱的抗胆碱酯酶活性。
Ketamine inhibits the anticholinesterase activity of ranitidine and physostigmine.
作者信息
Kounenis G, Koutsoviti-Papadopoulou M, Elezoglou V
机构信息
Department of Pharmacology, Faculty of Veterinary Medicine, Aristotelian University, Thessaloniki, Greece.
出版信息
Gen Pharmacol. 1994 Jul;25(4):631-4. doi: 10.1016/0306-3623(94)90238-0.
PMID:7958721
Abstract
- The present study was performed to investigate the effect of ketamine on the contractile responses induced by the H2-receptor antagonist ranitidine and the anticholinesterase agent physostigmine on the isolated guinea pig ileum. 2. The contractile responses induced by ranitidine and physostigmine on the guinea pig ileum were significantly prevented, in a concentration-dependent manner, by ketamine, while the ones induced by acetylcholine were not modified. The contractile responses induced by acetylcholine were inhibited by exogenous acetylcholinesterase. Ranitidine and physostigmine inhibited the above reduction, and this effect was significantly prevented by ketamine in a concentration-dependent manner. 3. These findings show that ketamine inhibits the contractile effect of ranitidine and physostigmine on the guinea pig ileum. This inhibition caused by ketamine seems to be associated with the protection of acetylcholinesterase against the inhibition by ranitidine and physostigmine.
摘要
- 本研究旨在探讨氯胺酮对H2受体拮抗剂雷尼替丁和抗胆碱酯酶药毒扁豆碱诱导的豚鼠离体回肠收缩反应的影响。2. 氯胺酮以浓度依赖的方式显著抑制雷尼替丁和毒扁豆碱诱导的豚鼠回肠收缩反应，而对乙酰胆碱诱导的收缩反应无影响。乙酰胆碱诱导的收缩反应可被外源性乙酰胆碱酯酶抑制。雷尼替丁和毒扁豆碱可抑制上述降低作用，氯胺酮以浓度依赖的方式显著抑制该作用。3. 这些结果表明，氯胺酮可抑制雷尼替丁和毒扁豆碱对豚鼠回肠的收缩作用。氯胺酮引起的这种抑制作用似乎与保护乙酰胆碱酯酶免受雷尼替丁和毒扁豆碱的抑制有关。
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