Kounenis G, Koutsoviti-Papadopoulou M, Elezoglou V
Department of Pharmacology, Faculty of Veterinary Medicine, Aristotelian University, Thessaloniki, Greece.
Pharmacol Res. 1995 Jun;31(6):337-40. doi: 10.1016/1043-6618(95)80086-7.
In the present study the effect of ketamine, a dissociative anaesthetic, on the GABA- and on the specific GABAA-agonist muscimol-induced responses of the isolated guinea pig ileum was investigated. GABA as well as muscimol produce a concentration-dependent contractile effect on the duodenum, jejunum and ileum. The sensitivity of the intestinal parts to both the above substances increases from the duodenum to the ileum. Ketamine produces a non-competitive inhibition of the GABA- and muscimol-induced contractions of the ileum, while it does not influence the ileal cholinergic contractions induced by exogenous acetylcholine. These results suggest that ketamine may modify intestinal motility through its antagonistic action at the GABAA-receptor complex.
在本研究中，研究了分离的豚鼠回肠中解离麻醉剂氯胺酮对γ-氨基丁酸（GABA）和特异性GABAA激动剂蝇蕈醇诱导反应的影响。GABA以及蝇蕈醇对十二指肠、空肠和回肠产生浓度依赖性收缩作用。肠道各部分对上述两种物质的敏感性从十二指肠到回肠逐渐增加。氯胺酮对GABA和蝇蕈醇诱导的回肠收缩产生非竞争性抑制，而不影响外源性乙酰胆碱诱导的回肠胆碱能收缩。这些结果表明，氯胺酮可能通过其对GABAA受体复合物的拮抗作用来改变肠道运动。
