Goto K, Meyerowitz E M
Division of Biology, California Institute of Technology, Pasadena 91125.
Genes Dev. 1994 Jul 1;8(13):1548-60. doi: 10.1101/gad.8.13.1548.
Mutations in the PISTILLATA (PI) gene of Arabidopsis thaliana cause homeotic conversion of petals to sepals and of stamens to carpels. It is thus classed as a B function floral homeotic gene and acts together with the product of the other known B function gene, APETALA3 (AP3). We have cloned PI and determined the time and places of its expression in developing flowers. Surprisingly, the initial patterns of PI and AP3 expression are different. By positive regulatory interactions between PI and AP3, later expression patterns are coincident or nearly coincident. The pattern of PI expression also depends on the activity of the floral development genes APETALA2 and SUPERMAN and on the activity of PI itself. The PI and APETALA3 proteins specifically associate in solution and so may act together in regulating PI and other genes.
拟南芥PISTILLATA（PI）基因的突变会导致花瓣向萼片以及雄蕊向心皮的同源异型转变。因此，它被归类为B类花同源异型基因，并与另一个已知的B类功能基因APETALA3（AP3）的产物共同发挥作用。我们已经克隆了PI基因，并确定了它在发育中的花朵中的表达时间和位置。令人惊讶的是，PI和AP3的初始表达模式是不同的。通过PI和AP3之间的正向调节相互作用，后期的表达模式是一致的或几乎一致的。PI的表达模式还取决于花发育基因APETALA2和SUPERMAN的活性以及PI自身的活性。PI和APETALA3蛋白在溶液中特异性结合，因此可能共同作用于调节PI和其他基因。
