编码MOK-2锌指蛋白的基因：其启动子的特征及小鼠Alu 2型重复元件的负调控
The gene encoding the MOK-2 zinc-finger protein: characterization of its promoter and negative regulation by mouse Alu type-2 repetitive elements.
作者信息
Arranz V, Kress M, Ernoult-Lange M
机构信息
Laboratoire d'Oncologie Moléculaire, Villejuif, France.
出版信息
Gene. 1994 Nov 18;149(2):293-8. doi: 10.1016/0378-1119(94)90164-3.
The mouse gene MOK-2 encodes a protein with seven highly similar zinc fingers. The MOK-2 transcripts are preferentially detected in transformed cell lines, brain and testis tissues. The characterized 5'-flanking sequence differs from those of tissue-specific genes previously described. DNA sequence analysis shows that the promoter region lacks TATA and CCAAT boxes. Two short interspersed mouse genomic repeats (B2 sequences) found in this region exert a negative cis-acting effect on MOK-2 promoter activity.
小鼠基因MOK - 2编码一种含有七个高度相似锌指结构的蛋白质。在转化细胞系、脑和睾丸组织中可优先检测到MOK - 2转录本。已鉴定的5'侧翼序列与先前描述的组织特异性基因的序列不同。DNA序列分析表明，启动子区域缺乏TATA盒和CCAAT盒。在该区域发现的两个短散在小鼠基因组重复序列（B2序列）对MOK - 2启动子活性发挥负性顺式作用。
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