Russel M G, Zeijen R N, Brummer R J, de Bruine A P, van Kroonenburgh M J, Stockbrügger R W
Department of Gastroenterology, University Hospital Maastricht, The Netherlands.
Gut. 1994 Oct;35(10):1490-2. doi: 10.1136/gut.35.10.1490.
A patient with a 15 year history of diarrhoea of unknown origin is described. Scintigraphy with technetium-99m labelled albumin suggested albumin loss at the terminal ileum and caecum; subsequent colonoscopic biopsies of these macroscopically normal looking areas showed abundant infiltration with eosinophils. A diagnosis of eosinophilic enterocolitis was made. Treatment with prednisolone had good results, but had to be stopped because of severe side effects. Oral cromoglycate and mesalazine were not effective. Budesonide (CIR), a new topically active corticosteroid with very little systemic effects, was at least as effective as prednisolone without producing side effects.
本文描述了一位有15年不明原因腹泻病史的患者。用99m锝标记白蛋白进行闪烁扫描显示末端回肠和盲肠有白蛋白丢失；随后对这些外观正常的区域进行结肠镜活检，结果显示有大量嗜酸性粒细胞浸润。诊断为嗜酸性小肠结肠炎。使用泼尼松龙治疗效果良好，但因严重副作用而不得不停药。口服色甘酸和柳氮磺胺吡啶无效。布地奈德（CIR）是一种新的局部活性皮质类固醇，全身作用极小，其疗效至少与泼尼松龙相当，且未产生副作用。
