Sedvall G
Abteilung für Psychiatrie und Psychologie, Karolinska-Instituts, Stockholm.
Fortschr Neurol Psychiatr. 1994 Sep;62 Suppl 1:39-43.
The brain imaging technics computerized tomography (CT), positron emission tomography (PET) and nuclear magnetic resonance imaging (MRI) represent significant tools for a further categorization of psychiatric patients with regard to brain structure and function. Of these technics PET has the unique sensitivity to examine several aspects of brain function as blood flow, metabolic rates and neurotransmitter mechanisms. Since several decades monoaminergic transmitter mechanisms have been implicated in the pathophysiology of schizophrenia and affective disorders as well as in the action of several psychoactive drugs. With regard to schizophrenia and the mechanism of action of antipsychotic drugs Dopamine receptors are in the focus of interest. In order to analyze distribution and binding characteristics of dopamine receptor subtypes in the living brain in relation to neuropsychiatric disorders and antipsychotic drug treatment we developed 11C-Labelled selective ligands binding to dopamine receptor subtypes and used them in vivo PET experiments on human subjects.
脑成像技术，如计算机断层扫描（CT）、正电子发射断层扫描（PET）和核磁共振成像（MRI），是对精神疾病患者的脑结构和功能进行进一步分类的重要工具。在这些技术中，PET在检测脑功能的多个方面，如血流、代谢率和神经递质机制方面具有独特的敏感性。几十年来，单胺能递质机制一直被认为与精神分裂症和情感障碍的病理生理学以及几种精神活性药物的作用有关。关于精神分裂症和抗精神病药物的作用机制，多巴胺受体是研究的焦点。为了分析多巴胺受体亚型在活体大脑中的分布和结合特征与神经精神疾病及抗精神病药物治疗的关系，我们开发了与多巴胺受体亚型结合的11C标记选择性配体，并将其用于人体受试者的活体PET实验。
