Plouët J, Bayard F
Laboratoire de Biologie Moléculaire de Eucaryotes, CNRS UPR, Toulouse, France.
Horm Res. 1994;42(1-2):14-9. doi: 10.1159/000184138.
Angiogenesis is a key step in organ development and remodelling during embryogenesis or tissue regeneration. Some pathological events such as tumor growth or diabetic retinopathy also lead to angiogenesis formation. Several molecules have already been identified as promoting angiogenesis in vivo. We have recently purified a new angiogenic growth factor. Its unique specificity for vascular endothelial cells led us to provisionally name it vasculotropin (VAS) or vascular endothelial growth factor (VEGF) or vascular permeability factor (VPF). In vitro, despite a moderate action on proliferation, VAS/VEGF strongly stimulates cell migration. In vivo, VAS/VEGF is a potent inducer of angiogenesis and vascular permeability. Its central role in angiogenesis is emphasized by the observation that its immunoneutralization prevents tumor progression.
血管生成是胚胎发育或组织再生过程中器官发育和重塑的关键步骤。一些病理事件，如肿瘤生长或糖尿病视网膜病变，也会导致血管生成。已经有几种分子被确定为在体内促进血管生成。我们最近纯化了一种新的血管生成生长因子。它对血管内皮细胞的独特特异性使我们暂时将其命名为血管促生素（VAS）或血管内皮生长因子（VEGF）或血管通透性因子（VPF）。在体外，尽管对增殖作用中等，但VAS/VEGF强烈刺激细胞迁移。在体内，VAS/VEGF是血管生成和血管通透性的有效诱导剂。其免疫中和可阻止肿瘤进展这一观察结果强调了它在血管生成中的核心作用。
