Pascal R R
Emory University School of Medicine, Atlanta, GA 30322.
Hum Pathol. 1994 Nov;25(11):1160-71. doi: 10.1016/0046-8177(94)90032-9.
The control of colorectal cancer is currently dependent on early detection, and its prevention requires the recognition and treatment of its precursor lesions. The adenoma has been established as the precursor of colorectal carcinoma in the general population. Among patients with inflammatory bowel disease (IBD), dysplasia is associated with, and precedes, invasive carcinoma. In this section criteria are described for the histological detection of preinvasive and early invasive neoplasia in the large intestine of patients with and without IBD. The therapeutic implications of these diagnoses are stressed. A brief review of subcellular changes, including genetic alterations, in colorectal neoplasia is included.
目前，结直肠癌的控制依赖于早期检测，其预防需要识别并治疗其前驱病变。腺瘤已被确认为普通人群中结直肠癌的前驱病变。在炎症性肠病（IBD）患者中，发育异常与浸润性癌相关且先于浸润性癌出现。本节描述了在患有和未患有IBD的患者大肠中检测浸润前和早期浸润性肿瘤形成的组织学标准。强调了这些诊断的治疗意义。还包括对结直肠肿瘤形成中亚细胞变化（包括基因改变）的简要综述。
