Abdeljaber M H, Nair M P, Schork M A, Schwartz S A
Department of Medicine, State University of New York at Buffalo 14203.
Immunol Invest. 1994 Aug;23(4-5):259-68. doi: 10.3109/08820139409066822.
Factors that suppress natural killer (NK) cell activity were examined in a random sample of 73 schizophrenic patients. NK activity in these patients were compared with 25 healthy age, sex and race matched controls. The mean percent of NK activity was 21% in the schizophrenic group compared with 30% percent in the controls. The difference between these two groups was statistically significant. The mean percent of NK activity in the chronic undifferentiated schizophrenic subgroup and schizoaffective subgroup were 20% and 22% respectively. The degree of suppression of NK activity in the chronic undifferentiated subgroup was higher than in the schizoaffective one, but the difference was not statistically significant. The two subgroups were comparable regarding other immune related variables such as total white cell count, neutrophils, lymphocytes, total protein, albumin, globulin, immunoglobulins and stress. The lower impairment of NK activity in the schizoaffective subgroup may be due to their exposure to lithium which can enhance immune functions. Factors associated with significant suppression of NK activity in schizophrenic patients were physical restraint, number of psychotropic medications, number of chronic non-psychiatric diagnoses and race. Psychosocial stressors were associated with suppression of NK activity but it was not statistically significant. Our results identify factors associated with reduced NK activity observed in certain schizophrenic patients and NK activity in these patients may be the result of interaction between various factors.
在73名精神分裂症患者的随机样本中，对抑制自然杀伤（NK）细胞活性的因素进行了研究。将这些患者的NK活性与25名年龄、性别和种族匹配的健康对照者进行比较。精神分裂症组的NK活性平均百分比为21%，而对照组为30%。两组之间的差异具有统计学意义。慢性未分化精神分裂症亚组和精神分裂症情感障碍亚组的NK活性平均百分比分别为20%和22%。慢性未分化亚组的NK活性抑制程度高于精神分裂症情感障碍亚组，但差异无统计学意义。在其他免疫相关变量方面，如白细胞总数、中性粒细胞、淋巴细胞、总蛋白、白蛋白、球蛋白、免疫球蛋白和应激，这两个亚组具有可比性。精神分裂症情感障碍亚组NK活性较低的损害可能是由于他们接触了可增强免疫功能的锂。与精神分裂症患者NK活性显著抑制相关的因素有身体约束、精神药物数量、慢性非精神科诊断数量和种族。心理社会应激源与NK活性抑制有关，但无统计学意义。我们的研究结果确定了与某些精神分裂症患者NK活性降低相关的因素，这些患者的NK活性可能是多种因素相互作用的结果。
