Radhakrishnan V V, Saraswathy A, Rout D, Mohan P K
Department of Pathology, Sree Chitra Tirunal Institute for Medical Science and Technology, Trivandrum.
Indian J Pathol Microbiol. 1994 Apr;37(2):171-8.
In this retrospective study, clinical and neuropathological features were analysed in eight patients with disseminated intracerebral microabscesses. All the patients presented with clinical features, suggestive of an encephalopathic process of an acute onset. Neuroradiological and laboratory investigations were not helpful in establishing the diagnosis in any patient during their hospital stay. All the eight patients died in the hospital and at autopsy disseminated intracerebral microabscesses were the most striking feature. In two patients hyphae of Candida albicans were demonstrated within the microabscesses. Gram negative bacilli in two patients and gram positive and gram positive cocci in one patient were demonstrated in the microabscesses. Disseminated intra-cerebral microabscesses are usually an unrecognised manifestation of central nervous system infections and should be considered in the differential diagnosis of patients with encephalopathy of unknown aetiology.
在这项回顾性研究中，对8例播散性脑内微脓肿患者的临床和神经病理学特征进行了分析。所有患者均表现出提示急性起病的脑病过程的临床特征。在患者住院期间，神经放射学和实验室检查对任何患者的诊断均无帮助。所有8例患者均在医院死亡，尸检时播散性脑内微脓肿是最显著的特征。在2例患者的微脓肿内发现了白色念珠菌菌丝。在2例患者的微脓肿内发现了革兰氏阴性杆菌，在1例患者的微脓肿内发现了革兰氏阳性球菌。播散性脑内微脓肿通常是中枢神经系统感染未被认识的表现，在病因不明的脑病患者的鉴别诊断中应予以考虑。
