Jungi T W, McGregor D D
J Immunol. 1978 Aug;121(2):456-63.
Delayed-type hypersensitivity (DTH) to Listeria monocytogenes was measured in rats that were recipients of syngeneic, semisyngeneic, and allogeneic immune thoracic duct lymphocytes (TDL). DTH could be transferred only to recipients that shared at least one haplotype with the TDL donors. The restriction was expressed in an inability of sensitized lymphoblasts to localize efficiently at antigen injection sites in the pinna of the ear and peritoneal cavity. Failure of allogeneic lymphoblasts to extravasate in more than trace numbers into Listeria-antigen-induced exudates was reflected in an absence of other lymphocyte-mediated expressions of DTH. Thus, lymphocyte-dependent MCA was not detected in Listeria-antigen-induced peritoneal exudates borne by recipients of allogeneic immune TDL and blood monocytes were not recruited in increased numbers into such exudates as they were in exudates borne by syngeneic rats. But allogeneic restriction of the delayed inflammatory response to Listeria antigen was overcome, at least in part, when antigen-presenting macrophages of the same MHC type as the immune TDL donors were implanted in the peritoneal cavity. The results encourage the belief that the observed failure of immune TDL to transfer DTH to allogeneic recipients is related to the inability of sensitized donor T cells to recognize antigen displayed by allogeneic macrophages.
在接受同基因、半同基因和异基因免疫胸导管淋巴细胞（TDL）的大鼠中，检测了对单核细胞增生李斯特菌的迟发型超敏反应（DTH）。DTH只能转移到与TDL供体至少共享一个单倍型的受体。这种限制表现为致敏淋巴细胞不能有效地在耳廓和腹腔的抗原注射部位定位。异基因淋巴细胞极少渗入李斯特菌抗原诱导的渗出液中，这反映在缺乏其他淋巴细胞介导的DTH表现上。因此，在异基因免疫TDL受体的李斯特菌抗原诱导的腹腔渗出液中未检测到淋巴细胞依赖性巨噬细胞移动抑制因子（MCA），并且与同基因大鼠的渗出液不同，血液单核细胞没有大量募集到此类渗出液中。但是，当与免疫TDL供体相同MHC类型的抗原呈递巨噬细胞植入腹腔时，对李斯特菌抗原的迟发性炎症反应的异基因限制至少部分得到克服。这些结果使人相信，观察到的免疫TDL不能将DTH转移给异基因受体与致敏供体T细胞无法识别异基因巨噬细胞呈递的抗原有关。
