Cousineau D F, Goresky C A, Rouleau J R, Rose C P
McGill University Medical Clinic, Montreal General Hospital, Quebec, Canada.
J Appl Physiol (1985). 1994 Jul;77(1):113-20. doi: 10.1152/jappl.1994.77.1.113.
The effects of coronary flow on cardiac capillary permeability-surface area products and interstitial spaces were examined at rest and after hemodilution in the canine heart. Multiple-indicator-dilution experiments and left atrial injections of microspheres were carried out in closed-chest anesthetized animals at rest and after plasma expansion with dextran. Plasma expansion was utilized to produce a large increase in coronary perfusion compared with control conditions. Values for plasma flow per unit interstitial space, derived from analysis of the indicator-dilution data, were found to correlate closely with average vascular plasma flow per gram, calculated from the cardiac microsphere data; the one reflects the other. With an increase in flow, cardiac capillary permeability-surface area product values were found to increase substantially, whereas the average sucrose extravascular or cardiac interstitial spaces remained stable. Consequently the dilution parameter, flow per unit interstitial space, which is independent of tracer loss, provided a good reflection of flow per weight of tissue in the heart, without the additional requirement for a flow probe.
在犬心静止状态及血液稀释后，研究了冠脉血流对心脏毛细血管通透表面积乘积及间质间隙的影响。在闭胸麻醉动物处于静止状态时以及用右旋糖酐进行血浆扩容后，进行了多指示剂稀释实验和向左心房注射微球的操作。与对照条件相比，血浆扩容用于使冠脉灌注大幅增加。从指示剂稀释数据分析得出的每单位间质间隙的血浆流量值，与根据心脏微球数据计算出的每克平均血管血浆流量密切相关；二者相互反映。随着血流增加，发现心脏毛细血管通透表面积乘积值大幅增加，而平均蔗糖血管外间隙或心脏间质间隙保持稳定。因此，与示踪剂损失无关的稀释参数，即每单位间质间隙的流量，很好地反映了心脏组织每重量的流量，无需额外使用流量探头。
