Coronary capillary permeability and tissue volumes for sucrose and water in dogs: a comparison of bolus and constant infusion multiple-indicator methods.

This study was undertaken to determine the accuracy with which heart interstitial and water volumes could be determined from multiple-indicator dilution experiments on the coronary circulation in open-chest dog preparations. Sucrose permeability by extraction calculations was found to average 0.26 +/- 0.02 cm3 . (min . g tissue)-1. The extravascular sucrose volume averaged 0.15 cm3 . g-1 tissue by both multiple-indicator and post-mortem methods. Indicator-dilution tritiated water curves labelled 85% of the post-mortem water content.