Davis J Q, Bennett V
Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina 27710.
J Biol Chem. 1994 Nov 4;269(44):27163-6.
Neurofascin, L1, NrCAM, NgCAM, and neuroglian are membrane-spanning cell adhesion molecules with conserved cytoplasmic domains that are believed to play important roles in development of the nervous system. This report presents biochemical evidence that the cytoplasmic domains of these molecules associate directly with ankyrins, a family of spectrin-binding proteins located on the cytoplasmic surface of specialized plasma membrane domains. Rat neurofascin and NrCAM together comprise over 0.5% of the membrane protein in adult brain tissue. Linkage of these ankyrin-binding cell adhesion molecules to spectrin-based structures may provide a major class of membrane-cytoskeletal connections in adult brain as well as earlier stages of development.
神经束蛋白、L1、NrCAM、NgCAM和神经胶质蛋白是具有保守细胞质结构域的跨膜细胞粘附分子，据信它们在神经系统发育中发挥重要作用。本报告提供了生化证据，表明这些分子的细胞质结构域与锚蛋白直接相关，锚蛋白是一类位于特殊质膜结构域细胞质表面的血影蛋白结合蛋白家族。大鼠神经束蛋白和NrCAM在成体脑组织中共同占膜蛋白的0.5%以上。这些与锚蛋白结合的细胞粘附分子与基于血影蛋白的结构的连接可能在成体脑以及发育早期阶段提供一类主要的膜-细胞骨架连接。
