恶性支气管活检标本组织病理学报告中的观察者变异性。
Observer variability in histopathological reporting of malignant bronchial biopsy specimens.
作者信息
Burnett R A, Swanson Beck J, Howatson S R, Lee F D, Lessells A M, McLaren K M, Ogston S, Robertson A J, Simpson J G, Smith G D
机构信息
University of Glasgow Department of Pathology, Western Infirmary.
出版信息
J Clin Pathol. 1994 Aug;47(8):711-3. doi: 10.1136/jcp.47.8.711.
AIMS
To evaluate the ability of histopathologists to classify lung carcinomas on bronchial biopsy material using the current World Health Organisation (WHO) classification.
METHODS
Eleven histopathologists each reviewed 100 randomly selected bronchial biopsy specimens which had originally been reported as showing lung carcinoma. A single haematoxylin and eosin stained section from each case was circulated and a standard proforma completed. These were analysed using kappa statistics.
RESULTS
The histopathologists were excellent at distinguishing between small cell and non-small-cell carcinoma kappa = 0.86), but not so good at subclassifying the non-small cell carcinoma group kappa = 0.25).
CONCLUSIONS
The clinically important distinction between small cell and non-small cell carcinoma of the lung is reliably made by competent histopathologists even on limited material.
目的
评估组织病理学家使用当前世界卫生组织（WHO）分类法对支气管活检材料中的肺癌进行分类的能力。
方法
11位组织病理学家每人审阅了100份随机选取的支气管活检标本，这些标本最初报告显示为肺癌。每个病例的一张苏木精和伊红染色切片被分发，并填写标准表格。使用kappa统计分析这些数据。
结果
组织病理学家在区分小细胞癌和非小细胞癌方面表现出色（kappa = 0.86），但在对非小细胞癌组进行亚分类方面表现不佳（kappa = 0.25）。
结论
即使材料有限，称职的组织病理学家也能可靠地区分肺小细胞癌和非小细胞癌这一具有临床重要性的差异。
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