百日咳患儿循环血中纤连蛋白及纤连蛋白受体的研究
Circulating fibronectin and fibronectin receptor in children with pertussis.
作者信息
Torre D, Giola M, Zeroli C, Martegani R, Bonetta G, Ferrario G
机构信息
Division of Infectious Diseases, Regional Hospital, Varese, Italy.
出版信息
J Clin Pathol. 1994 Sep;47(9):793-5. doi: 10.1136/jcp.47.9.793.
AIM
To determine concentrations of fibronectin and fibronectin receptor in children with pertussis.
METHODS
Concentrations of circulating fibronectin and serum fibronectin receptor were detected in eight children affected by pertussis, eight children with acute upper or lower respiratory tract infections, and in 14 healthy control children. The single radial immunodiffusion technique and a solid phase enzyme immunoassay were used to detect circulating serum concentrations of fibronectin and fibronectin receptor.
RESULTS
On admission, a significant decrease in fibronectin was detected in children with pertussis (p = 0.0006). Significant and decreased concentrations of fibronectin were also observed in children with upper or lower respiratory tract infections (p = 0.0002). On the other hand, serum fibronectin receptor concentrations were significantly increased in patients with pertussis, whereas patients with upper or lower respiratory tract infections had normal circulating fibronectin receptor concentrations.
CONCLUSIONS
Fibronectin deficiency in children with pertussis may be related to diffusion and deposition of this protein in bronchial and alveolar spaces to limit infection, while increased fibronectin receptor concentrations are probably the expression of T cell activation and cell-mediated immunity during Bordetella pertussis infection.
目的
测定百日咳患儿纤连蛋白和纤连蛋白受体的浓度。
方法
检测8例百日咳患儿、8例急性上呼吸道或下呼吸道感染患儿以及14例健康对照儿童的循环纤连蛋白和血清纤连蛋白受体浓度。采用单向放射免疫扩散技术和固相酶免疫测定法检测纤连蛋白和纤连蛋白受体的循环血清浓度。
结果
入院时，百日咳患儿的纤连蛋白显著降低（p = 0.0006）。上呼吸道或下呼吸道感染患儿的纤连蛋白浓度也显著降低（p = 0.0002）。另一方面，百日咳患者的血清纤连蛋白受体浓度显著升高，而上呼吸道或下呼吸道感染患者的循环纤连蛋白受体浓度正常。
结论
百日咳患儿的纤连蛋白缺乏可能与该蛋白在支气管和肺泡空间的扩散和沉积以限制感染有关，而纤连蛋白受体浓度升高可能是百日咳博德特氏菌感染期间T细胞活化和细胞介导免疫的表现。
Zotero 插件