Mosher D F
Annu Rev Med. 1984;35:561-75. doi: 10.1146/annurev.me.35.020184.003021.
Fibronectin is a major protein of blood and tissues. It has been intensively studied because of its many interactions with cells and other macromolecules. Fibronectin is a principal component of the extracellular matrix, and its most important function seems to be in tissue remodelling during embryogenesis and wound healing. It may influence a number of other physiological processes, including phagocytosis. The concentration of plasma fibronectin and the distribution of tissue fibronectin are altered in disease states, although diseases specifically caused by quantitative or qualitative abnormalities of fibronectin have not been identified.
纤连蛋白是血液和组织中的一种主要蛋白质。由于它与细胞及其他大分子有许多相互作用，因此受到了深入研究。纤连蛋白是细胞外基质的主要成分，其最重要的功能似乎是在胚胎发育和伤口愈合过程中的组织重塑。它可能影响许多其他生理过程，包括吞噬作用。尽管尚未发现由纤连蛋白的定量或定性异常具体引起的疾病，但在疾病状态下血浆纤连蛋白的浓度和组织纤连蛋白的分布会发生改变。
