Rao B K, Freeman R G, Poulos E G, Arbesfeld L, Rendon M
Department of Dermatology, Boston University School of Medicine, Massachusetts.
J Dermatol Surg Oncol. 1994 Nov;20(11):761-4. doi: 10.1111/j.1524-4725.1994.tb03201.x.
Various skin tumors can be seen rarely in association with seborrheic keratosis. We present 60 cases of seborrheic keratosis related to a basal cell epithelioma in the same specimen.
To report association of basal cell epithelioma with seborrheic keratosis and discuss the possibility of malignant change in seborrheic keratosis.
Sixty cases of seborrheic keratosis associated with basal cell epithelioma were studied. Tissues were fixed in neutral buffered formalin, processed, and stained with standard hematoxylin and eosin techniques.
Histological evaluation showed a seborrheic keratosis associated with basal cell epithelioma in all of the cases. Basal cell epithelioma was attached with seborrheic keratosis in a majority of the cases (40/60) and appeared to represent a part of the same tumor. Both tumors were lying adjacent to each other in the rest of the cases (20/60).
Malignant change in seborrheic keratosis is controversial. We recommend the histological evaluation of seborrheic keratosis especially when inflamed or atypical in appearance. This should not be taken as a mandate for pathological evaluation or for treatment of every seborrheic keratosis as though it was potentially malignant.
各种皮肤肿瘤很少与脂溢性角化病同时出现。我们报告了60例在同一标本中与基底细胞上皮瘤相关的脂溢性角化病病例。
报告基底细胞上皮瘤与脂溢性角化病的关联，并探讨脂溢性角化病发生恶变的可能性。
对60例与基底细胞上皮瘤相关的脂溢性角化病病例进行研究。组织用中性缓冲福尔马林固定、处理，并采用标准苏木精和伊红染色技术染色。
组织学评估显示所有病例均为与基底细胞上皮瘤相关的脂溢性角化病。大多数病例（40/60）中基底细胞上皮瘤与脂溢性角化病相连，似乎代表同一肿瘤的一部分。其余病例（20/60）中两种肿瘤彼此相邻。
脂溢性角化病的恶变存在争议。我们建议对脂溢性角化病进行组织学评估，尤其是当其外观有炎症或不典型时。但这不应该被视为对每一例脂溢性角化病都进行病理评估或治疗的指令，好像它有潜在恶变可能一样。
