Stein M B, Asmundson G J, Chartier M
Department of Psychiatry, University of Manitoba, Winnipeg, Canada.
J Affect Disord. 1994 Jul;31(3):211-21. doi: 10.1016/0165-0327(94)90031-0.
To determine whether patients with generalized social phobia exhibit evidence of abnormal autonomic nervous system (ANS) functioning, 15 non-depressed, medication-free subjects with DSM-IV social phobia (generalized type) and 15 healthy control subjects participated in a series of autonomic function tests. Generalized social phobics exhibited increased blood pressure responsivity to Valsalva and exaggerated vagal withdrawal in response to isometric exercise, but normal cardiovascular responsivity to all other tasks. Plasma norepinephrine and epinephrine levels were also normal. Studies with larger sample sizes and the use of specific neuropharmacologic probes seem warranted to further delineate a role for autonomic dysfunction in the pathophysiology of this disorder.
为了确定广泛性社交恐惧症患者是否存在自主神经系统（ANS）功能异常的证据，15名无抑郁症状、未服用药物的DSM-IV社交恐惧症（广泛性类型）患者和15名健康对照者参与了一系列自主神经功能测试。广泛性社交恐惧症患者对瓦尔萨尔瓦动作的血压反应性增加，对等长运动的迷走神经撤离反应夸张，但对所有其他任务的心血管反应正常。血浆去甲肾上腺素和肾上腺素水平也正常。似乎有必要进行更大样本量的研究并使用特定的神经药理学探针，以进一步阐明自主神经功能障碍在该疾病病理生理学中的作用。
