Mathur S, Flora S J, Mathur R, Kannan G M, Das Gupta S
School of Studies in Zoology, Jiwaji University, Gwalior, India.
J Appl Toxicol. 1994 Jul-Aug;14(4):263-7. doi: 10.1002/jat.2550140404.
The effects of meso-2,3-dimercaptosuccinic acid (DMSA) and 2,3-dimercaptopropane sulphonate (DMPS) on body beryllium burden, hepatic lipid peroxidation, glutathione, alkaline and acid phosphatase and some biochemical variables of porphyrin metabolism were studied in beryllium-poisoned rats. It was observed that beryllium poisoning is associated with a slight increase in lipid peroxidation, significant depletion of alkaline phosphatase and elevation of acid phosphatase activities in the liver and increased beryllium concentration in blood and other soft organs. Evidence is presented that both DMSA and DMPS during concomitant administration prevented most of the above beryllium-induced biochemical alterations. Tissue beryllium concentration and histopathological lesions in liver and kidneys were also significantly less marked following simultaneous administration of DMPS compared to beryllium-exposed controls; DMSA was comparatively less effective.
在铍中毒大鼠中研究了内消旋-2,3-二巯基琥珀酸（DMSA）和2,3-二巯基丙烷磺酸盐（DMPS）对机体铍负荷、肝脏脂质过氧化、谷胱甘肽、碱性和酸性磷酸酶以及卟啉代谢的一些生化指标的影响。观察到铍中毒与脂质过氧化略有增加、肝脏碱性磷酸酶显著耗竭和酸性磷酸酶活性升高以及血液和其他软组织器官中铍浓度增加有关。有证据表明，同时给予DMSA和DMPS可预防上述大多数铍诱导的生化改变。与铍暴露对照组相比，同时给予DMPS后，肝脏和肾脏中的组织铍浓度和组织病理学损伤也明显减轻；DMSA的效果相对较差。
