Bhattacharya M K, Bhattacharya S K, Paul M, Dutta D, Dutta P, Kole H, De D, Ghosh A R, Das P, Nair G B
National Institute of Cholera & Enteric Diseases (NICED), Beliaghata, Calcutta, India.
J Diarrhoeal Dis Res. 1994 Jun;12(2):121-4.
Of 230 cases of bloody diarrhoea studied, 100 (43.5%) were positive for Shigellae by stool culture, of which Shigella dysenteriae type 1 was isolated from 56 cases, S. flexneri from 35, S. boydii from 5 and S. sonnei from 4. The major clinical manifestations of the patients infected with Shigella spp. were abdominal pain, anorexia, vomiting, tenesmus, and fever. Fever of above 100.5 degrees F and frequency of stool of more than 15 per day were noticed more among cases infected with S. dysenteriae type 1 and S. flexneri. Vomiting was more frequently observed in cases infected with S. sonnei or S. boydii (44.4%) as compared to those infected with S. dysenteriae type 1 (10.7%) and S. flexneri (8.6%). All Shigella isolates were uniformly susceptible to norfloxacin and ciprofloxacin but were resistant to streptomycin. S. dysenteriae type 1 isolates were susceptible to nalidixic acid (69.6%), ampicillin (5.4%), TMP-SMX (12.5%), furazolidone (98.2%) and gentamycin (80.4%), whereas all other Shigella isolates (S. flexneri, S. boydii, and S. sonnei) were uniformly susceptible to nalidixic acid, > 94% susceptible to furazolidone, and only moderately susceptible to ampicillin (28.6% to 55.5%) and TMP-SMX (22.2% to 48.6%).
在研究的230例血性腹泻病例中，粪便培养志贺菌阳性者100例（43.5%），其中从56例中分离出1型痢疾志贺菌，35例分离出福氏志贺菌，5例分离出鲍氏志贺菌，4例分离出宋内志贺菌。感染志贺菌属的患者主要临床表现为腹痛、厌食、呕吐、里急后重和发热。1型痢疾志贺菌和福氏志贺菌感染的病例中，体温高于100.5华氏度及每日排便次数超过15次的情况更为常见。与1型痢疾志贺菌（10.7%）和福氏志贺菌（8.6%）感染的病例相比，宋内志贺菌或鲍氏志贺菌感染的病例呕吐更为频繁（44.4%）。所有志贺菌分离株对诺氟沙星和环丙沙星均敏感，但对链霉素耐药。1型痢疾志贺菌分离株对萘啶酸敏感（69.6%）、氨苄西林敏感（5.4%）、复方新诺明敏感（12.5%）、呋喃唑酮敏感（98.2%）和庆大霉素敏感（80.4%），而所有其他志贺菌分离株（福氏志贺菌、鲍氏志贺菌和宋内志贺菌）对萘啶酸均敏感，对呋喃唑酮敏感率>94%，对氨苄西林仅中度敏感（28.6%至55.5%），对复方新诺明中度敏感（22.2%至48.6%）。
