Cook D J, Reeve B K, Scholes L C
Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
Infect Control Hosp Epidemiol. 1994 Jul;15(7):437-42. doi: 10.1086/646948.
We performed a meta-analysis to evaluate whether stress ulcer prophylaxis with histamine-2-receptor antagonists or antacids reduces mortality in critically ill patients. It appears that sucralfate results in a lower incidence of nosocomial pneumonia than either antacids or histamine-2-receptor antagonists. With respect to mortality, strong trends favored sucralfate over both antacids and histamine-receptor antagonists.
我们进行了一项荟萃分析，以评估使用组胺-2受体拮抗剂或抗酸剂进行应激性溃疡预防是否能降低重症患者的死亡率。与抗酸剂或组胺-2受体拮抗剂相比，硫糖铝似乎能降低医院获得性肺炎的发生率。在死亡率方面，有明显趋势表明硫糖铝优于抗酸剂和组胺受体拮抗剂。
