Buckley M G, Markandu N D, Sagnella G A, MacGregor G A
Department of Medicine, St George's Hospital Medical School, London, UK.
J Hypertens. 1994 Jul;12(7):809-13.
To examine the changes in plasma brain natriuretic peptide (BNP), atrial natriuretic peptide (ANP) and blood pressure in patients with essential hypertension on a low, normal and high sodium intake.
Twelve patients with mild-to-moderate essential hypertension were studied. Plasma, urinary and blood pressure measurements were made with the patients on their usual sodium intake, then on the fifth day of a low (10 mmol/day) and on the fifth day of a high (350 mmol/day) sodium intake, the sequence being allocated randomly.
Plasma levels of BNP and ANP increased significantly on the high sodium intake compared with when the patients were on their normal diet. The mean blood pressure on the high sodium intake was not significantly different from that with the patients on their normal diet. In contrast, plasma BNP and ANP decreased on the low sodium intake, but were not significantly different compared with when the patients were on their normal diet. However, there was a significant reduction in the mean blood pressure on the low sodium intake compared with when the patients were on their normal diet. Compared with the normal diet, BNP and ANP plasma levels showed similar percentage decreases on the low sodium intake and similar percentage increases on the high sodium intake.
These findings suggest that BNP and ANP are released in response to a common stimulus during changes in dietary sodium intake. The changes in plasma BNP and ANP observed with sodium restriction and sodium loading indicate the potential importance of BNP and ANP as a dual peptide system contributing to the maintenance of sodium balance and blood pressure regulation in patients with essential hypertension, during changes in dietary sodium intake.
研究原发性高血压患者在低钠、正常钠和高钠摄入情况下血浆脑钠肽（BNP）、心房钠尿肽（ANP）及血压的变化。
对12例轻至中度原发性高血压患者进行研究。在患者维持日常钠摄入量时进行血浆、尿液及血压测量，之后随机安排患者分别在低钠（10 mmol/天）摄入的第5天和高钠（350 mmol/天）摄入的第5天再次进行测量。
与正常饮食时相比，高钠摄入时血浆BNP和ANP水平显著升高。高钠摄入时的平均血压与正常饮食时相比无显著差异。相比之下，低钠摄入时血浆BNP和ANP水平下降，但与正常饮食时相比无显著差异。然而，低钠摄入时的平均血压与正常饮食时相比显著降低。与正常饮食相比，低钠摄入时BNP和ANP血浆水平下降的百分比相似，高钠摄入时升高的百分比相似。
这些发现表明，在饮食钠摄入量变化期间，BNP和ANP是对共同刺激做出反应而释放的。钠限制和钠负荷时观察到的血浆BNP和ANP变化表明，在饮食钠摄入量变化期间，BNP和ANP作为一种双重肽系统，在原发性高血压患者维持钠平衡和血压调节方面具有潜在的重要性。
