Májský A, Jakoubková J, Abrahámová J
J Immunogenet. 1976 Dec;3(6):429-33. doi: 10.1111/j.1744-313x.1976.tb00605.x.
Modifications of HLA antigens (transient loss or polyreactivity) were found in thirty-two of fifty-five examined patients with blood diseases (leukaemia, reticulosis, reticulo- and lymphosarcoma, lymphogranuloma, erythroblastoma) and malignant tumours. In two cases of acute myelosis transient alteration of HLA-A 2 antigen in HLA-A 28 was demonstrated. The relationship of HLA antigenic modification to chemotherapy was established, both by analysis of individual cases and by statistical evaluation of serological results in patients with or without chemotherapy (0-01 greater than P greater than 0-001). Chemotherapy is thus one of the causes for the development of HLA antigen modifications in blood diseases and malignant tumours.
在55例接受检查的血液病（白血病、网状细胞增多症、网状细胞肉瘤和淋巴肉瘤、淋巴肉芽肿、成红细胞瘤）和恶性肿瘤患者中，发现32例存在HLA抗原改变（短暂丢失或多反应性）。在2例急性髓性白血病患者中，证实HLA - A2抗原在HLA - A28中发生短暂改变。通过对个别病例的分析以及对接受或未接受化疗患者血清学结果的统计学评估，确定了HLA抗原修饰与化疗之间的关系（0.01＞P＞0.001）。因此，化疗是血液病和恶性肿瘤中HLA抗原修饰发生的原因之一。
