去甲丙咪嗪治疗帕金森病
Nomifensine in parkinsonism.
作者信息
Teychenne P F, Park D M, Findley L J, Rose F C, Calne D B
出版信息
J Neurol Neurosurg Psychiatry. 1976 Dec;39(12):1219-21. doi: 10.1136/jnnp.39.12.1219.
Abstract
Nomifensine, a tetrahydroisoquinolone antidepressant which facilitates dopaminergic and noradrenergic transmission, was studied in 28 Parkinsonism patients most of whom were also receiving conventional medications. Double-blind evaluations revealed a moderate therapeutic action at a mean dose level of 150 mg daily. Adverse reactions were encountered, similar to those identical by levodopa.
摘要
诺米芬辛是一种促进多巴胺能和去甲肾上腺素能传递的四氢异喹啉类抗抑郁药，对28例帕金森病患者进行了研究，其中大多数患者也在接受传统药物治疗。双盲评估显示，在每日平均剂量150毫克时具有中度治疗作用。出现了不良反应，与左旋多巴引起的不良反应相似。
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Nomifensine in parkinsonism.去甲丙咪嗪治疗帕金森病
J Neurol Neurosurg Psychiatry. 1976 Dec;39(12):1219-21. doi: 10.1136/jnnp.39.12.1219.
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Nomifensine: effect in Parkinsonian patients not receiving levodopa.诺米芬辛：对未接受左旋多巴治疗的帕金森病患者的作用。
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5
Nomifensine in parkinsonism.诺米芬辛治疗帕金森病。
Br J Clin Pharmacol. 1977;4Suppl 2(Suppl 2):185S-186S. doi: 10.1111/j.1365-2125.1977.tb05750.x.
本文引用的文献
1
8-Amino-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline, a new antidepressant.8-氨基-2-甲基-4-苯基-1,2,3,4-四氢异喹啉，一种新型抗抑郁药。
Arzneimittelforschung. 1973 Jan;23(1):45-50.
2
Effect of nomifensine (HOE 984), a new antidepressant, on uptake of noradrenaline and serotonin and on release of noradrenaline in rat brain synaptosomes.新型抗抑郁药诺米芬辛（HOE 984）对大鼠脑突触体中去甲肾上腺素和5-羟色胺摄取及去甲肾上腺素释放的影响。
Biochem Pharmacol. 1974 Dec 15;23(24):3413-22. doi: 10.1016/0006-2952(74)90344-x.
3
Bromocriptine in Parkinsonism.帕金森病中的溴隐亭
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4
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Naunyn Schmiedebergs Arch Pharmacol. 1974;286(1):49-63. doi: 10.1007/BF00499104.
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Actions of dopaminergic agonists on motor function.多巴胺能激动剂对运动功能的作用。
Adv Neurol. 1975;9:285-97.
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Nomifensine: a potent dopaminergic agonist of antiparkinson potential.诺米芬辛：一种具有抗帕金森病潜力的强效多巴胺能激动剂。
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