Teychenne P F, Park D M, Findley L J, Rose F C, Calne D B
J Neurol Neurosurg Psychiatry. 1976 Dec;39(12):1219-21. doi: 10.1136/jnnp.39.12.1219.
Nomifensine, a tetrahydroisoquinolone antidepressant which facilitates dopaminergic and noradrenergic transmission, was studied in 28 Parkinsonism patients most of whom were also receiving conventional medications. Double-blind evaluations revealed a moderate therapeutic action at a mean dose level of 150 mg daily. Adverse reactions were encountered, similar to those identical by levodopa.