丙戊酸钠治疗左旋多巴诱发的运动障碍。
Sodium valproate in the treatment of levodopa-induced dyskinesia.
作者信息
Price P A, Parkes J D, Marsden C D
出版信息
J Neurol Neurosurg Psychiatry. 1978 Aug;41(8):702-6. doi: 10.1136/jnnp.41.8.702.
Abstract
The effect of sodium valproate 1200 mg daily on the disability of Parkinsonism and on levodopa-induced dyskinesia was assessed in a double-blind crossover trial with matched placebo in 12 patients with Parkinson's disease. No objective change in the severity of Parkinsonism or dyskinesias was noted. However, six out of nine patients who completed the trial noted a slight to moderate improvement in their dyskinesias with no change in their Parkinsonism. Excess salivation improved in four subjects on sodium valproate.
摘要
在一项针对12例帕金森病患者的双盲交叉试验中，使用匹配的安慰剂，评估了每日1200毫克丙戊酸钠对帕金森病残疾程度和左旋多巴诱发的运动障碍的影响。未观察到帕金森病或运动障碍严重程度的客观变化。然而，完成试验的9例患者中有6例指出其运动障碍有轻微至中度改善，而帕金森病症状无变化。4例服用丙戊酸钠的受试者流涎过多的情况有所改善。
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