Lindberg G, Larsson G, Setterlind S, Råstam L
Centre for Public Health Research, Karlstad, Sweden.
J Epidemiol Community Health. 1994 Aug;48(4):360-3. doi: 10.1136/jech.48.4.360.
To explore the link between serum cholesterol and suicide by investigating the relation between serum lipids and depressive symptoms.
This was a cross sectional study of the relation between serum cholesterol, low density lipoprotein (LDL) cholesterol, high density lipoprotein (HDL) cholesterol, and triglycerides on the one hand and depressive symptoms as expressed in a questionnaire on the other.
An organisational development programme in industry with assistance from occupational health care.
A total of 644 male and 261 female employees (mainly white-collar workers) participated.
Total cholesterol and LDL cholesterol values were lower in those men who, sometimes, often, or very often, had experienced low mood or glumness during the past month compared with those who had not. Serum triglyceride concentrations did not differ between the groups. In women, however, the serum triglyceride value, but not the total cholesterol or LDL cholesterol, was lower in those who reported low mood, depression, or anxiety during the past six months.
Decreasing appetite as a consequence of depression in men would probably lead to both decreasing cholesterol and triglyceride concentrations. Thus, these data indicate the presence of some other explanation for the relation between the level of LDL cholesterol and depressive symptoms in men.
通过调查血脂与抑郁症状之间的关系，探讨血清胆固醇与自杀之间的联系。
这是一项横断面研究，一方面研究血清胆固醇、低密度脂蛋白（LDL）胆固醇、高密度脂蛋白（HDL）胆固醇和甘油三酯之间的关系，另一方面研究问卷调查中所表达的抑郁症状之间的关系。
在职业卫生保健的协助下，开展的一项行业组织发展项目。
共有644名男性和261名女性员工（主要是白领）参与。
与过去一个月内未经历过情绪低落或忧郁的男性相比，有时、经常或非常经常经历情绪低落或忧郁的男性，其总胆固醇和LDL胆固醇值较低。两组之间血清甘油三酯浓度无差异。然而，在女性中，过去六个月内报告有情绪低落、抑郁或焦虑的女性，其血清甘油三酯值较低，但总胆固醇或LDL胆固醇值无差异。
男性因抑郁导致食欲下降，可能会导致胆固醇和甘油三酯浓度均下降。因此，这些数据表明，对于男性LDL胆固醇水平与抑郁症状之间的关系，存在其他一些解释。
