Lee Kounseok, Kim Sunhae, Jo Jung Ki
Department of Psychiatry, Hanyang University Medical Center, Seoul 04763, Korea.
Department of Urology, Hanyang University Medical Center, Seoul 04763, Korea.
J Clin Med. 2022 Apr 11;11(8):2119. doi: 10.3390/jcm11082119.
(1) Background: Serum lipid levels affect not only nutritional status but also emotional state. The purpose of this study was to examine the effects of various socio-demographic characteristics, abnormal cholesterol levels, and BMI indicators on depressive symptoms and suicidal ideation in the Korean population. (2) Methods: A total of 23,692 people were surveyed using data from the Korea National Health and Nutrition Examination Survey (KNHNES) 2014, 2016, and 2018. Data from 11,653 patients were analyzed. Age, sex, chronic disease, smoking, alcohol consumption, total cholesterol (HDL, triglycerides), BMI, depression, and suicidal ideation were measured. (3) Results: According to sex, low HDL, high triglycerides, and suicidal ideation were significant, along with low education level, smoking, binge drinking, and high BMI. High triglyceride level was shown to significantly increase the risk of depression in males (OR = 1.535, 95% CI = 1.098-2.147). Factors affecting suicidal ideation in males were age, binge drinking, and depression, while blood lipid factors were not significant. (4) Conclusions: Of the types of serum lipid factors affecting depression and suicidal ideation, high triglycerides were found to be a risk factor for depression in men. Serum lipids can be used as biomarkers to reflect depressive symptoms in men depending on cholesterol level.
(1) 背景：血清脂质水平不仅影响营养状况，还影响情绪状态。本研究的目的是探讨各种社会人口学特征、胆固醇水平异常和体重指数指标对韩国人群抑郁症状和自杀意念的影响。(2) 方法：使用2014年、2016年和2018年韩国国家健康与营养检查调查（KNHNES）的数据对总共23,692人进行了调查。对11,653名患者的数据进行了分析。测量了年龄、性别、慢性病、吸烟、饮酒、总胆固醇（高密度脂蛋白、甘油三酯）、体重指数、抑郁和自杀意念。(3) 结果：按性别来看，低高密度脂蛋白、高甘油三酯和自杀意念具有显著性，同时低教育水平、吸烟、暴饮和高体重指数也具有显著性。高甘油三酯水平显示会显著增加男性患抑郁症的风险（比值比=1.535，95%置信区间=1.098-2.147）。影响男性自杀意念的因素是年龄、暴饮和抑郁，而血脂因素不显著。(4) 结论：在影响抑郁和自杀意念的血清脂质因素类型中，发现高甘油三酯是男性患抑郁症的一个风险因素。血清脂质可根据胆固醇水平用作反映男性抑郁症状的生物标志物。
