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Interleukin 1 alpha activates two forms of p54 alpha mitogen-activated protein kinase in rabbit liver.白细胞介素1α激活兔肝脏中的两种形式的p54α丝裂原活化蛋白激酶。
J Exp Med. 1994 Dec 1;180(6):2017-25. doi: 10.1084/jem.180.6.2017.
2
Interleukin-1 activates a novel protein kinase that phosphorylates the epidermal-growth-factor receptor peptide T669.白细胞介素-1激活一种新型蛋白激酶，该激酶可使表皮生长因子受体肽T669磷酸化。
Biochem J. 1994 Sep 15;302 ( Pt 3)(Pt 3):897-905. doi: 10.1042/bj3020897.
3
Interleukin-1 represents a new modality for the activation of extracellular signal-regulated kinases/microtubule-associated protein-2 kinases.白细胞介素-1代表了一种激活细胞外信号调节激酶/微管相关蛋白-2激酶的新方式。
J Biol Chem. 1991 Nov 25;266(33):22661-70.
4
MAPKAP kinase-2; a novel protein kinase activated by mitogen-activated protein kinase.丝裂原活化蛋白激酶激活的蛋白激酶-2；一种由丝裂原活化蛋白激酶激活的新型蛋白激酶。
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5
Identification of epidermal growth factor Thr-669 phosphorylation site peptide kinases as distinct MAP kinases and p34cdc2.鉴定作为不同丝裂原活化蛋白激酶和p34cdc2的表皮生长因子苏氨酸-669磷酸化位点肽激酶。
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6
The chemotactic factor N-formylmethionyl-leucyl-phenylalanine activates microtubule-associated protein 2 (MAP) kinase and a MAP kinase kinase in polymorphonuclear leucocytes.趋化因子N-甲酰甲硫氨酰-亮氨酰-苯丙氨酸可激活多形核白细胞中的微管相关蛋白2（MAP）激酶和一种MAP激酶激酶。
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7
Purification and cDNA cloning of SAPKK3, the major activator of RK/p38 in stress- and cytokine-stimulated monocytes and epithelial cells.应激和细胞因子刺激的单核细胞及上皮细胞中RK/p38的主要激活因子SAPKK3的纯化及cDNA克隆
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8
Epidermal growth factor (EGF) receptor T669 peptide kinase from 3T3-L1 cells is an EGF-stimulated "MAP" kinase.来自3T3-L1细胞的表皮生长因子（EGF）受体T669肽激酶是一种受EGF刺激的“丝裂原活化蛋白（MAP）”激酶。
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9
Interleukin 1 and tumour necrosis factor activate the mitogen-activated protein (MAP) kinase kinase in cultured cells.白细胞介素1和肿瘤坏死因子可激活培养细胞中的丝裂原活化蛋白（MAP）激酶激酶。
FEBS Lett. 1993 Nov 15;334(2):189-92. doi: 10.1016/0014-5793(93)81709-9.
10
Identification of a human epidermal growth factor receptor-associated protein kinase as a new member of the mitogen-activated protein kinase/extracellular signal-regulated protein kinase family.鉴定一种人表皮生长因子受体相关蛋白激酶作为丝裂原活化蛋白激酶/细胞外信号调节蛋白激酶家族的新成员。
J Biol Chem. 1993 Aug 25;268(24):18213-7.

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4
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5
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Neurochem Res. 1998 Feb;23(2):235-42. doi: 10.1023/a:1022493228015.
6
Staurosporine, but not Ro 31-8220, induces interleukin 2 production and synergizes with interleukin 1alpha in EL4 thymoma cells.星形孢菌素可诱导EL4胸腺瘤细胞产生白细胞介素2，而Ro 31-8220则不能，且星形孢菌素在EL4胸腺瘤细胞中可与白细胞介素1α协同作用。
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7
Interleukin 1-induced phosphorylation of MAD3, the major inhibitor of nuclear factor kappa B of HeLa cells. Interference in signalling by the proteinase inhibitors 3,4-dichloroisocoumarin and tosylphenylalanyl chloromethylketone.白细胞介素1诱导的MAD3磷酸化，MAD3是HeLa细胞核因子κB的主要抑制剂。蛋白酶抑制剂3,4-二氯异香豆素和甲苯磺酰苯丙氨酰氯甲基酮对信号传导的干扰。
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8
Protein synthesis inhibitors reveal differential regulation of mitogen-activated protein kinase and stress-activated protein kinase pathways that converge on Elk-1.蛋白质合成抑制剂揭示了有丝分裂原激活蛋白激酶和应激激活蛋白激酶途径在Elk-1上的差异调节。
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9
The activation of distinct mitogen-activated protein kinase cascades is required for the stimulation of 2-deoxyglucose uptake by interleukin-1 and insulin-like growth factor-1 in KB cells.在KB细胞中，白细胞介素-1和胰岛素样生长因子-1刺激2-脱氧葡萄糖摄取需要激活不同的丝裂原活化蛋白激酶级联反应。
Biochem J. 1995 Nov 1;311 ( Pt 3)(Pt 3):735-8. doi: 10.1042/bj3110735.

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10
Interleukin-1 represents a new modality for the activation of extracellular signal-regulated kinases/microtubule-associated protein-2 kinases.白细胞介素-1代表了一种激活细胞外信号调节激酶/微管相关蛋白-2激酶的新方式。
J Biol Chem. 1991 Nov 25;266(33):22661-70.

白细胞介素1α激活兔肝脏中的两种形式的p54α丝裂原活化蛋白激酶。

Interleukin 1 alpha activates two forms of p54 alpha mitogen-activated protein kinase in rabbit liver.

作者信息

Kracht M, Truong O, Totty N F, Shiroo M, Saklatvala J

机构信息

Cytokine Laboratory, Department of Development and Signalling, Babraham Institute, Cambridge, UK.

出版信息

J Exp Med. 1994 Dec 1;180(6):2017-25. doi: 10.1084/jem.180.6.2017.

DOI:10.1084/jem.180.6.2017
PMID:7964479
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2191785/
Abstract

We have identified in rabbits two hepatic forms of T669 peptide kinases that are very strongly activated after systemic injection with the inflammatory cytokine interleukin 1 (IL-1). The T669 peptide contains a major phosphorylation site of the epidermal growth factor receptor, threonine 699 and is a substrate for mitogen-activated protein (MAP) kinases. The kinases were purified to homogeneity and corresponded to 50- and 55-kD proteins on sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Amino acid sequencing of 12 tryptic peptides of both kinases identified them as p54 MAP kinase alpha. This kinase belongs to the novel family of stress-activated protein kinases. This is the first evidence of IL-1 activating a specific protein kinase in vivo.

摘要

我们在兔子体内鉴定出了两种肝型T669肽激酶，在全身性注射炎性细胞因子白细胞介素1（IL-1）后，它们会被强烈激活。T669肽包含表皮生长因子受体的一个主要磷酸化位点，即苏氨酸699，并且是丝裂原活化蛋白（MAP）激酶的底物。这些激酶被纯化至同质，在十二烷基硫酸钠-聚丙烯酰胺凝胶电泳上对应于50-kD和55-kD的蛋白质。对两种激酶的12个胰蛋白酶肽段进行氨基酸测序，确定它们为p54 MAP激酶α。这种激酶属于应激激活蛋白激酶的新家族。这是IL-1在体内激活特定蛋白激酶的首个证据。