Holst P B, Anthoni U, Christophersen C, Nielsen P H
Marine Chemistry Section, H.C. Orsted Institute, University of Copenhagen, Denmark.
J Nat Prod. 1994 Jul;57(7):997-1000. doi: 10.1021/np50109a020.
A new alkaloid, flustramine E [1], with inhibitory activity towards Rhizotonia solani and Botrytis cinerea was isolated by gas-phase extraction from the marine bryozoan Flustra foliacea. The structure was determined as 3a,8a-cis-1-methyl-3a-(3-methyl-2- butenyl)-6-bromo-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole, based on spectroscopic investigations. Another alkaloid, debromoflustramine B [2a], was detected in trace amounts and identified by comparison of the mass spectrum with that of a synthetic sample. The extract also contained the previously reported alkaloids flustramine A and B in the ratio 1:7.
通过气相萃取法从海洋苔藓虫叶苔虫中分离出一种对茄丝核菌和灰葡萄孢具有抑制活性的新生物碱——苔藓胺E [1]。基于光谱研究，其结构被确定为3a,8a-顺式-1-甲基-3a-(3-甲基-2-丁烯基)-6-溴-1,2,3,3a,8,8a-六氢吡咯并[2,3-b]吲哚。还检测到痕量的另一种生物碱——脱溴苔藓胺B [2a]，并通过将其质谱与合成样品的质谱进行比较来鉴定。提取物中还含有先前报道的生物碱苔藓胺A和B，其比例为1:7。
