Yao Biao, Prinsep Michèle R, Nicholson Brian K, Gordon Dennis P
Department of Chemistry, University of Waikato, Private Bag 3105, Hamilton, New Zealand.
J Nat Prod. 2003 Aug;66(8):1074-7. doi: 10.1021/np030104y.
Two new alkaloids, pterocellins A and B, have been isolated from the New Zealand marine bryozoan Pterocella vesiculosa. Structural elucidation was achieved through NMR and mass spectral analysis in conjunction with a single-crystal X-ray diffraction study of pterocellin A. The pterocellins possess a novel heterocyclic skeleton and exhibit potent antitumor activity and antimicrobial activity in vitro but only modest activity in the in vivo hollow fiber assay at the National Cancer Institute.
从新西兰海洋苔藓虫类泡状翼苔藓虫（Pterocella vesiculosa）中分离出了两种新生物碱——翼苔藓虫素A和B。通过核磁共振（NMR）和质谱分析，并结合翼苔藓虫素A的单晶X射线衍射研究，确定了其结构。翼苔藓虫素具有一种新型杂环骨架，在体外表现出强效的抗肿瘤活性和抗菌活性，但在美国国立癌症研究所的体内中空纤维试验中仅表现出适度的活性。
