亨廷顿病患者大脑中与谷氨酸/N-甲基-D-天冬氨酸受体甘氨酸位点结合的[3H]L-689,560存在缺失。
Deficit of [3H]L-689,560 binding to the glycine site of the glutamate/NMDA receptor in the brain in Huntington's disease.
作者信息
Reynolds G P, Pearson S J, Hutson P H
机构信息
Department of Biomedical Science, University of Sheffield, UK.
出版信息
J Neurol Sci. 1994 Aug;125(1):46-9. doi: 10.1016/0022-510x(94)90240-2.
Binding of [3H]L-689,560 to the glycine site of the glutamate/NMDA receptor was carried out using post-mortem brain tissue from patients with Huntington's disease (HD) and from matched controls. Decreased binding site density (by 62% in the caudate nucleus, 20% in the frontal cortex) was identified in HD. The deficit found in the caudate nucleus in HD correlated with deficits of GABA and glutamate concentrations and thus may reflect the ongoing disease process.
使用亨廷顿病（HD）患者及相匹配的对照者的死后脑组织，开展了[3H]L-689,560与谷氨酸/ N-甲基-D-天冬氨酸受体甘氨酸位点的结合实验。结果发现，HD患者的结合位点密度降低（尾状核降低62%，额叶皮质降低20%）。HD患者尾状核中发现的缺陷与γ-氨基丁酸（GABA）和谷氨酸浓度的缺陷相关，因此可能反映了疾病的进展过程。
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