Cross A J, Slater P, Reynolds G P
Neurosci Lett. 1986 Jun 18;67(2):198-202. doi: 10.1016/0304-3940(86)90397-6.
The binding of D-[3H]aspartic acid to the high-affinity glutamate uptake system was studied in membrane preparations of postmortem brains from controls and Huntington's disease (HD) subjects. The groups were matched for age and postmortem delay. A large (60-72%) and significant reduction in D-[3H]aspartate binding was observed in both the caudate nucleus and putamen, but not in the frontal cortex of the HD brains. The loss of striatal D-[3H]aspartate binding may reflect a loss of the high-affinity glutamate uptake system contained on the terminals of corticostriatal afferents. In contrast, the binding of [3H]paroxetine to the serotonin uptake system was marginally increased in the caudate nucleus and unchanged in the putamen. It is suggested that the reduction of high-affinity glutamate uptake sites may contribute to the production of the striatal lesion in HD.
在来自对照组和亨廷顿舞蹈症（HD）患者的死后大脑膜制剂中，研究了D-[3H]天冬氨酸与高亲和力谷氨酸摄取系统的结合情况。两组在年龄和死后延迟方面相匹配。在HD大脑的尾状核和壳核中，观察到D-[3H]天冬氨酸结合大幅（60 - 72%）且显著减少，但在额叶皮质中未出现这种情况。纹状体中D-[3H]天冬氨酸结合的丧失可能反映了皮质纹状体传入神经末梢上所含高亲和力谷氨酸摄取系统的丧失。相比之下，[3H]帕罗西汀与5-羟色胺摄取系统的结合在尾状核中略有增加，在壳核中则无变化。有人提出，高亲和力谷氨酸摄取位点的减少可能促成了HD中纹状体病变的产生。
